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SYGNIS AG

euro adhoc: Disclosure announcement after § 15 WpHG
LION Bioscience AG
Management Changes
Management Board Change

Disclosure announcement transmitted by euro adhoc.
  The issuer is responsible for the content of this announcement.
LION bioscience AG, Cambridge, MA, USA, Heidelberg, Germany, October
14, 2004 – LION bioscience (Nasdaq: LEON) today announced that
effective immediately Dr. Daniel Keesman, COO and co-CEO, and Martin
Hollenhorst, CFO and co–CEO resigned. Primarily due to its NASDAQ
listing the company could not extend its Directors & Officers
insurance at economically feasible terms. The Supervisory Board
accepted their decisions and thanked the Management Team for their
work and contributions.
The Supervisory Board appointed Mr. Joseph F. Donahue and Dr. Thure
Etzold as co-CEOs, also effective immediately. Mr. Donahue continues
to serve as Chief Business Officer and also assumes responsibilities
for Finance and Administration. Dr. Etzold was named Chief Technology
Officer, responsible for Product Development and Services.
Dr. Etzold, 44, joined the company in July 1998 and most recently
served as Senior Vice President Research & Development and Managing
Director of LION bioscience Ltd (United Kingdom). Dr. Etzold joined
LION from the EBI (European Bioinformatics Institute). Prior to his
tenure at the EBI he was a scientist at the EMBL (European Molecular
Biology Laboratory) in Heidelberg, Germany. He is credited with
developing a Retrieval System for Molecular Biological Databanks
(SRS) by establishing novel methods for accessing and interconnecting
various heterogeneous data sources.  He holds a Ph.D. in Molecular
Biology from the Max-Planck-Institute in Köln, Germany.
Mr. Donahue, 41, joined the company in May 2003 and most recently
served as Chief Business Officer and President of LION bioscience,
Inc. (North America).  Mr. Donahue joined LION from Spotfire, Inc.
where he served as Vice President of Global Life Sciences and
Chemicals Markets. Prior to joining Spotfire, he was Vice President
of North American Sales at MDL Information Systems where he played an
instrumental role in expanding MDL’s market presence and
strengthening customer relationships. During a fifteen-year tenure at
MDL, he held numerous positions of increasing responsibility in sales
and marketing. He received degrees in Chemistry and Computer Science
from Villanova University in Villanova, Pennsylvania, USA.
LION recently has successfully refocused on its key assets and
markets and has been executing on plan to expand its product and
customer base. LION released three new products this year to the
Bioinformatics and Cheminformatics markets as a fundamental basis for
future growth. Revenues and costs for the second quarter, to be
announced on Nov. 4, are in line with expectations.
end of announcement                    euro adhoc 14.10.2004 09:22:35 

Further inquiry note:

Günter Dielmann, Tel.: +49 6221 4038-249,
guenter.dielmann@lionbioscience.com
Julia Fritz, Tel.: +49 6221 4038-158,
julia.fritz@lionbioscience.com
Tracy Coffey, Tel.: +1 857 919 9975,
tracy.coffey@lionbioscience.com

Branche: Pharmaceuticals
ISIN: DE0005043509
WKN: 504350
Index: Nemax 50, Prime Standard
Börsen: Frankfurter Wertpapierbörse / regulated dealing
New York / regulated dealing
Berliner Wertpapierbörse / free trade
Hamburger Wertpapierbörse / free trade
Baden-Württembergische Wertpapierbörse / free trade
Börse Düsseldorf / free trade
Niedersächsische Börse zu Hannover / free trade
Bayerische Börse / free trade
Bremer Wertpapierbörse (BWB) / free trade

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